Professor Bill Hague

Professor Bill Hague
 Position Professor
 Org Unit Women's and Children's Health
 Email bill.hague@adelaide.edu.au
 Mobile +61 4 1111 4575
 Location WCH - Norwich Centre ,   Womens & Childrens Hospital

  • Biography/ Background

     

    Made in China, produced in Hong Kong and brought up in the UK, Bill Hague worked from 1990 in Obstetric Medicine at the Women’s and Children’s Hospital (W&CH) in Adelaide, South Australia.  After undergraduate training at Trinity College, Cambridge and St Thomas' Hospital, London, he did postgraduate training in Cambridge, Sheffield and London, in particular with Professor Michael de Swiet at Queen Charlotte's Hospital, London, and with Professor Howard Jacobs at the Middlesex Hospital, London, with specialist qualifications in Obstetric Medicine, Reproductive Endocrinology and Obstetrics and Gynaecology, and a Cambridge MD in Familial Aspects of Polycystic Ovaries.  The service he helped to build up at the W&CH is recognised around Australia and overseas for its quality and commitment.  His clinical service work, teaching and research achievements were recognised by The University of Adelaide with a promotion to full Professor in November 2011.  His contributions include the first robust demonstration of the efficacy and safety of metformin in women with gestational diabetes (the MiG Study) in collaboration with Dr Janet Rowan from Auckland, published in the NEJM in 2008.  He founded the Obstetric Medicine Group of Australasia (OMGA), and in 2009 became the first Honorary Member of the Society of Obstetric Medicine of Australia and New Zealand (SOMANZ), following the amalgamation of OMGA and the Australasian Society for the Study of Hypertension in Pregnancy (ASSHP), of which he is a former President.  He is also involved in the Australasian Maternity Outcomes Surveillance System (AMOSS).

    Until his retirement from hospital practice in October 2022, he was Senior Consultant Physician in Obstetric Medicine, Women & Children's Hospital, Adelaide, having previously been a member of the Visiting Staff at Women & Children's Hospital, The Queen Elizabeth Hospital and Flinders Medical Centre.

    He is now a Research Leader in Obstetric Medicine at the Robinson Research Institute, The University of Adelaide, focussing on Medical Disorders of Pregnancy, including Gestational Diabetes, Pre-eclampsia, and Hepatic disorders, in particular, Intrahepatic Cholestasis of Pregnancy.

     

    Other Appointments
    • Chair of the South Australian Maternal Mortality sub-committee of the Maternal and Perinatal Committee
    • Previous Member of the Australian National Advisory Committee on Maternal Mortality and Serious Morbidity
    • South Australian Coordinator, Australasian Maternity Outcomes Surveillance System (AMOSS)
    • Previous Regional Secretary Oceania Region, International Christian Medical and Dental Association
    • Previous Oceania Desk-holder, Partners in International Medical Education
    • Previous National Chairman of the Christian Medical and Dental Fellowship of Australia
    • Previous Member of Advisory Council for South Australian Stillbirth and Neonatal Death Support Group

  • Qualifications

    • 2001 FRCP (London) 
    • 1993 FRCOG
    • 1988 MD (Cantab)
    • 1987 Certificate of Accreditation (JCHMT), Endocrinology and Obstetric Medicine
    • 1983 MRCOG
    • 1978 MRCP(UK)
    • 1975 MA (Cantab)
    • 1975 MB, BChir (Cantab)
    • 1972 BA (Cantab)

     

  • Research Interests

    • The benefits/harms of diagnosing and treating gestational diabetes (GDM) in early pregnancy compared with leaving the diagnosis of GDM and treatment as required until 28 weeks gestation
    • The comparison of pregnancy and health economic outcomes in women diagnosed as GDM using ADIPS-1998 criteria compared with those diagnosed using IADPSG criteria
    • The comparison of pregnancy and health economic outcomes in women diagnosed as GDM randomised to "tight" and "very tight" glucose control
    • The prevalence of MODY genotypes in South Australian women with GDM
    • Follow-up of offspring of women with GDM treated with metformin or insulin
    • Metformin as an alternative to insulin in the management of women with GDM
    • Metformin in the prevention of recurrent GDM
    • Metformin effects on insulin resistance in women with GDM
    • Metformin effects on vitamin B12 metabolism in women with GDM
    • Pharmacokinetics of metformin in women with GDM
    • Metformin for women who are obese during pregnancy for improving maternal and infant outcomes
    • Postpartum SMS reminders to women who have had GDM to test for type 2 diabetes: a randomised controlled trial: The DIAMIND study
    • The place of low molecular weight heparin in the prevention of recurrent utero-placental thrombosis and associated diseases in women with thrombophilia
    • The role of genetic and acquired thrombophilia, including polymorphisms of methylenetetrahydrofolate reductase, activated protein C resistance, prothrombin gene mutation, protein S deficiency, hyperhomocysteinaemia and antiphospholipid antibodies in the aetiology of pre-eclampsia, placental abruption, intra-uterine growth restriction and recurrent miscarriage
    • The role of genetic thrombophilia, including polymorphisms of methylenetetrahydrofolate reductase, activated protein C resistance and the prothrombin gene mutation in the aetiology of cerebral palsy
    • The relationship of pre-eclampsia to the subsequent development of vascular disease and its link to hyperhomocysteinaemia
    • The effect of folate supplementation on the prevention of pre-eclampsia: the Folic Acid Clinical Trial (FACT)
    • Investigations in the Folic Acid Clinical Trial - the INFACT study
    • The effect of folate supplementation on the prevention of recurrent pre-eclampsia in women with hyperhomocysteinaemia
    • Follow-up of the offspring of the FACT study: the FACT-for-Child study
    • Longitudinal study of genome stability in the mother, fetus, neonate and child in relation to folate and B12 status
    • The role of common polymorphisms in the methylenetetrahydrofolate reductase, methionine synthase and thymidylate synthase genes as determinants of genome stability in mothers, fetuses, neonates and children
    • The control of hypertension in pregnancy: the CHIPS study
    • Follow-up of the offspring of the CHIPS study: the CHIPS-CHILD study
    • Treatment of severe early-onset intrahepatic cholestasis of pregnancy (ICP), comparing treatment with ursodeoxycholic acid with rifampicin: the TURRIFIC study
    • Genetic Mechanisms of bile transporters
    • The long-term outcomes of children exposed in utero to ICP
    • The aetiology of microvesicular hepatic steatosis and its relationship to clinical outcomes in women and sheep
    • The Australasian Maternity Outcomes Surveillance System (AMOSS)

     

  • Publications

    Publications since 2010

    • Lot-to-lot reagent changes and commutability of quality testing materials for total bile acid measurements
      C. Markus, S. Coat, H. U. Marschall, S. Matthews, T. P. Loh, W. Rankin, W. M. Hague.
      Clin Chem Lab Med 2023. DOI: 10.1515/cclm-2022-1278
    • Bile acid reference intervals for evidence-based practice
      C. Ovadia, A. L. Mitchell, C. Markus, W. M. Hague and C. Williamson
      BJOG 2022.  DOI: 10.1111/1471-0528.17171
    • Performance of four regression frameworks with varying precision profiles in simulated reference material commutability assessment
      C. Markus, R. Z. Tan, C. Y. Lim, W. Rankin, S. J. Matthews, T. P. Loh, W. M. Hague.
      Clin Chem Lab Med 2022, 60(8) 1164-1174
    • Infant Exposure to Armodafinil Through Human Milk Following Maternal Use of Modafinil
      C. Leggett, U. Ritchie, L. Costi, D. Elliot, A. A. Mangoni and W. M. Hague
      Journal of Human Lactation 2022. DOI: 10.1177/08903344221134273
    • GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements
      P. H. Dixon, A. P. Levine, I. Cebola, M. M. Y. Chan, A. S. Amin, A. Aich, .. W. M. Hague, .. et al.
      Nature Communications 2022, 13(1) 4840.  DOI: 10.1038/s41467-022-29931-z
    • Cortical Plasticity and Interneuron Recruitment in Adolescents Born to Women with Gestational Diabetes Mellitus
      J. M. Van_Dam, M. R. Goldsworthy, W. M. Hague, S. Coat and J. B. Pitcher
      Brain Sciences 2021, 11(3) doi:10.3390/brainsci11030388
    • Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
      C. Ovadia, J. Sajous, P. T. Seed, K. Patel, N. J. Williamson, G. Attilakos, ..  W. M. Hague, .. et al.
      Lancet Gastroenterol Hepatol 2021, 6(7) 547-558
    • The BACH project protocol: an international multicentre total Bile Acid Comparison and Harmonisation project and sub-study of the TURRIFIC randomised trial
      C. Markus, S. Coat, H.-U. Marschall, C. Williamson, P. Dixon, M. Fuller, W. M. Hague.
      Clinical Chemistry and Laboratory Medicine (CCLM) 2021  DOI: doi:10.1515/cclm-2021-0496
    • A multi-centre, open label, randomised, parallel-group, superiority Trial to compare the efficacy of URsodeoxycholic acid with RIFampicin in the management of women with severe early onset Intrahepatic Cholestasis of pregnancy: the TURRIFIC randomised trial
      W. M. Hague, L. Callaway, J. Chambers, L. Chappell, S. Coat, J. de Haan-Jebbink, et al.
      BMC Pregnancy Childbirth 2021, 21(1) 51-65
    • Pharmacological interventions for treating intrahepatic cholestasis of pregnancy
      K. F. Walker, L. C. Chappell, W. M. Hague, P. Middleton and J. G. Thornton
      Cochrane Database of Systematic Reviews 2020, 7.  DOI: 10.1002/14651858.CD000493.pub3
    • Metformin for preventing Type 2 Diabetes Mellitus in women with a previous diagnosis of gestational diabetes: a narrative review
      V. L. Versace, H. Beks, H. Wesley, K. McNamara, W. Hague, R. M. Anjana, et al.
      Semin Reprod Med 2020, 38 1-11
    • Whole-genome sequencing of patients with rare diseases in a national health system
      E. Turro, W. J. Astle, K. Megy, S. Graf, D. Greene, O. Shamardina, .. W.M. Hague, .. et al.
      Nature 2020, 583(7814) 96-102
    • Whole-genome sequencing of a sporadic primary immunodeficiency cohort
      J. E. D. Thaventhiran, H. Lango Allen, O. S. Burren, W. Rae, D. Greene, E. Staples, ..  W.M. Hague, .. et al.
      Nature 2020, 583(7814) 90-95
    • Options for screening for gestational diabetes mellitus during the SARS-CoV-2 pandemic
      D. Simmons, V. L. Rudland, V. Wong, J. Flack, A. Mackie, G. P. Ross, W. M. Hague.
      Aust N Z J Obstet Gynaecol 2020, 60(5) 660-666
    • Metformin in Pregnancy Study (MiPS): protocol for a systematic review with individual patient data meta-analysis
      A. Mousa, T. Løvvik, I. Hilkka, S. M. Carlsen, L. Morin-Papunen, K. Tertti, .. W. M. Hague, ..  et al.
      BMJ Open 2020, 10(5) e036981
    • Perindopril in Breast Milk and Determination of Breastfed Infant Exposure: A Prospective Observational Study
      C. Leggett, E. M. P. Lwin, U. Ritchie, Y. Song, J. P. Gerber, S. Turner, W. M. Hague.
      Drug Des Devel Ther 2020, 14  961-967
    • Biliary transporter gene mutations in severe intrahepatic cholestasis of pregnancy: Diagnostic and management implications
      S. P. Yeap, H. Harley, R. Thompson, K. D. Williamson, J. Bate, F. Sethna, W. M. Hague.
      J Gastroenterol Hepatol 2019, 34(2) 425-435
    • Germline selection shapes human mitochondrial DNA diversity
      W. Wei, S. Tuna, M. J. Keogh, K. R. Smith, T. J. Aitman, P. L. Beales, ..  W. M. Hague, .. et al.
      Science 2019, 364(6442). DOI: 10.1126/science.aau6520
    • Serious kidney disease in pregnancy: an Australian national cohort study protocol
      N. Safi, E. Sullivan, Z. Li, M. Brown, W. Hague, S. McDonald, et al.
      BMC Nephrol 2019, 20(1). DOI: 10.1186/s12882-019-1393-z
    • Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis
      C. J. Rhodes, K. Batai, M. Bleda, M. Haimel, L. Southgate, M. Germain, ..  W. M. Hague, .. et al.
      Lancet Respiratory Medicine 2019, 7(3) 227-238
    • Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses
      C. Ovadia, P. T. Seed, A. Sklavounos, V. Geenes, C. Di Ilio, J. Chambers, ..  W. M. Hague, .. et al.
      Lancet 2019, 393(10174) 899-909
    • Liver and Gastrointestinal Disorders During Pregnancy
      W. M. Hague and I. C. Roberts-Thomson
      In: Gastroenterology For General Surgeons, edited by M. W. Wichmann, T. K. McCullough, I. C. Roberts-Thomson and G. J. Maddern
      Springer Nature 2019, pp 237-244
    • Effect of metformin in addition to dietary and lifestyle advice for pregnant women who are overweight or obese: the GRoW randomised, double-blind, placebo-controlled trial
      J. M. Dodd, J. Louise, A. R. Deussen, R. M. Grivell, G. Dekker, A. J. McPhee, W. M. Hague.
      Lancet Diabetes Endocrinol 2019, 7(1)15-24
    • Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial
      S. W. Wen, R. R. White, N. Rybak, L. M. Gaudet, S. Robson, W. Hague, et al.
      BMJ 2018, 362.  DOI: 10.1136/bmj.k3478
    • Reduced Cortical Excitability, Neuroplasticity, and Salivary Cortisol in 11-13-Year-Old Children Born to Women with Gestational Diabetes Mellitus
      J. M. Van Dam, A. J. Garrett, L. A. Schneider, N. A. Hodyl, M. R. Goldsworthy, S. Coat, W. M. Hague, J. Pitcher.
      EBioMedicine 2018, 31 143-149
    • Hyperglycaemia in early pregnancy: the Treatment of Booking Gestational diabetes Mellitus (TOBOGM) study. A randomised controlled trial
      D. Simmons, W. M. Hague, H. J. Teede, N. W. Cheung, E. J. Hibbert, C. J. Nolan, et al.
      Med J Aust 2018, 209(9) 405-406
    • Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age
      J. A. Rowan, E. C. Rush, L. D. Plank, J. Lu, V. Obolonkin, S. Coat, W. M. Hague.
      BMJ Open Diabetes Research & Care 2018, 6(1) e000456
    • Transfer of rosuvastatin into breast milk: liquid chromatography–mass spectrometry methodology and clinical recommendations
      E. M. P. Lwin, C. Leggett, U. Ritchie, C. Gerber, Y. Song, W. Hague, et al.
      Drug Design, Development and Therapy 2018, 12 3645-3651
    • Estimation of Atenolol Transfer Into Milk and Infant Exposure During Its Use in Lactating Women
      E. M. P. Lwin, C. Gerber, C. Leggett, Y. Song, U. Ritchie, S. Turner, W. Hague, et al.
      J Hum Lact 2018, 34(3) 592-599
    • Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes
      J. M. Dodd, R. M. Grivell, A. R. Deussen, W. M. Hague
      Cochrane Database Syst Rev 2018. DOI: 10.1002/14651858.CD010564.pub2
    • Results of the first recorded evaluation of a national gestational diabetes mellitus register: Challenges in screening, registration, and follow-up for diabetes risk
      D. I. R. Boyle, V. L. Versace, J. A. Dunbar, W. Scheil, E. Janus, J. J. N. Oats, .. W. Hague, .. et al.
      PLoS One 2018, 13(8) e0200832
    • Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes
      J. Tieu, S. Coat, W. Hague, P. Middleton, E. Shepherd
      Cochrane Database Syst Rev 2017. DOI: 10.1002/14651858.CD007724.pub3
    • A retrospective cohort review of intrahepatic cholestasis of pregnancy in a South Australian population
      J. A. Marathe, W. H. Lim, M. P. Metz, W. Scheil, G. A. Dekker, W. M. Hague
      Eur J Obstet Gynecol Reprod Biol 2017, 218 33-38
    • The use of dextrose/insulin infusions during labour and delivery in women with gestational diabetes mellitus: Is there any point?
      M. T. Farrant, K. Williamson, M. Battin, W. M. Hague, J. A. Rowan
      Aust N Z J Obstet Gynaecol 2017, 57(3) 378-380
    • Infant birth outcomes are associated with DNA damage biomarkers as measured by the cytokinesis block micronucleus cytome assay: the DADHI study
      M. Dass Singh, P. Thomas, M. Hor, T. Almond, J. Owens, W. Hague, et al.
      Mutagenesis 2017, 32(3) 355-370
    • Neurodevelopmental outcome at 2 years in offspring of women randomised to metformin or insulin treatment for gestational diabetes
      T. A. Wouldes, M. Battin, S. Coat, E. C. Rush, W. M. Hague, J. A. Rowan
      Arch Dis Child Fetal Neonatal Ed 2016. DOI: 10.1136/archdischild-2015-309602
    • Diagnostic Criteria and Treatment for Gestational Diabetes Mellitus
      D. N. Voormolen, S. K. Abell, R. James, W. M. Hague, B. W. Mol
      Semin Reprod Med 2016, 34(2) 102-9
    • Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study)
      M. Vidler, L. A. Magee, P. von Dadelszen, E. Rey, S. Ross, E. Asztalos, ..  W. Hague, .. et al.
      Eur J Obstet Gynecol Reprod Biol 2016, 206 105-113
    • Women's views on postpartum testing for type 2 diabetes after gestational diabetes: Six month follow-up to the DIAMIND randomised controlled trial
      E. M. Van Ryswyk, P. F. Middleton, W. M. Hague, C. A. Crowther
      Prim Care Diabetes 2016, 10(2) 91-102
    • Mothers after Gestational Diabetes in Australia (MAGDA): A Randomised Controlled Trial of a Postnatal Diabetes Prevention Program
      S. L. O'Reilly, J. A. Dunbar, V. Versace, E. Janus, J. D. Best, R. Carter, ..  W. Hague, .. et al.
      PLoS Med 2016, 13(7) DOI: 10.1371/journal.pmed.1002092
    • The CHIPS Randomized Controlled Trial (Control of Hypertension in Pregnancy Study): Is Severe Hypertension Just an Elevated Blood Pressure?
      L. A. Magee, P. von Dadelszen, J. Singer, T. Lee, E. Rey, S. Ross, .. W. Hague, .. et al.
      Hypertension 2016, 68(5) 1153-1159
    • Can adverse maternal and perinatal outcomes be predicted when blood pressure becomes elevated? Secondary analyses from the CHIPS (Control of Hypertension In Pregnancy Study) randomized controlled trial
      L. A. Magee, P. von Dadelszen, J. Singer, T. Lee, E. Rey, S. Ross, .. W. Hague, .. et al.
      Acta Obstet Gynecol Scand 2016, 95(7) 763-76
    • Control of Hypertension In Pregnancy Study randomised controlled trial-are the results dependent on the choice of labetalol or methyldopa?
      L. A. Magee, C. S. Group, P. von Dadelszen, J. Singer, T. Lee, E. Rey, .. W. Hague, .. et al.
      BJOG 2016, 123(7) 1135-41
    • Do labetalol and methyldopa have different effects on pregnancy outcome? Analysis of data from the Control of Hypertension In Pregnancy Study (CHIPS) trial
      L. A. Magee, C. S. Group, P. von Dadelszen, J. Singer, T. Lee, E. Rey, .. W. Hague, .. et al.
      BJOG 2016, 123(7) 1143-51
    • Metformin and dietary advice to improve insulin sensitivity and promote gestational restriction of weight among pregnant women who are overweight or obese: the GRoW Randomised Trial
      J. M. Dodd, R. M. Grivell, A. R. Deussen, G. Dekker, J. Louise, W. Hague
      BMC Pregnancy Childbirth 2016, 16(1) Pages 359-366
    • The Cost Implications of Less Tight Versus Tight Control of Hypertension in Pregnancy (CHIPS Trial)
      R. J. Ahmed, A. Gafni, E. K. Hutton, Z. J. Hu, E. Pullenayegum, P. von Dadelszen, ...  W. Hague,  .. et al.
      Hypertension 2016, 68(4) 1049-55
    • Does low-molecular-weight heparin influence fetal growth or uterine and umbilical arterial Doppler in women with a history of early-onset uteroplacental insufficiency and an inheritable thrombophilia? Secondary randomised controlled trial results
      C. Abheiden, M. E. Van Hoorn, W. M. Hague, P. J. Kostense, M. G. van Pampus, J. de Vries
      BJOG 2016, 123(5) 797-805
    • Authors' reply (x2) re: Does low-molecular-weight heparin influence fetal growth or uterine and umbilical arterial Doppler in women with a history of early-onset uteroplacental insufficiency and an inheritable thrombophilia? Secondary randomised controlled trial results
      C. Abheiden, M. van Hoorn, W. Hague, P. Kostense, M. van Pampus, J. de Vries
      BJOG 2016, 123(5) 843, 844-5
    • Postpartum SMS reminders to women who have experienced gestational diabetes to test for Type 2 diabetes: the DIAMIND randomized trial
      E. M. Van Ryswyk, P. F. Middleton, W. M. Hague, C. A. Crowther
      Diabet Med 2015 Vol. 32(10) 1368-76
    • Women's views and knowledge regarding healthcare seeking for gestational diabetes in the postpartum period: A systematic review of qualitative/survey studies
      E. Van Ryswyk, P. Middleton, E. Shute, W. Hague, C. Crowther
      Diabetes Res Clin Pract 2015 DOI: 10.1016/j.diabres.2015.09.010
    • Low-molecular-weight heparin and aspirin in the prevention of recurrent early-onset pre-eclampsia in women with antiphospholipid antibodies: the FRUIT-RCT
      M. E. van Hoorn, W. M. Hague, M. G. van Pampus, D. Bezemer, J. I. de Vries and FRUIT investigators
      Eur J Obstet Gynecol Reprod Biol 2015, 197 168-173
    • Potential role of folate in pre-eclampsia
      M. D. Singh, P. Thomas, J. Owens, W. Hague, M. Fenech
      Nutr Rev 2015, 73(10) 694-722
    • Dalteparin for pregnant women with thrombophilia - authors' reply
      M. A. Rodger, W. M. Hague, J. Kingdom, S. R. Kahn and P. S. Wells
      Lancet 2015, 385(9969) 690
    • Less-Tight versus Tight Control of Hypertension in Pregnancy
      L. A. Magee, [for the CHIPS Study Group, includes Hague W.M.], P. von Dadelszen, E. Rey, S. Ross, E. Asztalos, K. E. Murphy, et al.
      New England Journal of Medicine 2015, 372(5) 407-417
    • Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy
      V. Geenes, J. Chambers, R. Khurana, E. W. Shemer, W. Sia, D. Mandair, W. Hague, et al.
      Eur J Obstet Gynecol Reprod Biol 2015, 189 59-63
    • Blood pressure measurement at two years in offspring of women randomized to a trial of metformin for GDM: follow up data from the MiG trial
      M. R. Battin, V. Obolonkin, E. Rush, W. Hague, S. Coat, J. Rowan
      BMC Pediatr 2015, 15 54-59
    • Does low-molecular-weight heparin influence fetal growth or uterine and umbilical arterial Doppler in women with a history of early-onset uteroplacental insufficiency and an inheritable thrombophilia? Secondary randomised controlled trial results
      C. Abheiden, M. E. Van Hoorn, W. M. Hague, P. J. Kostense, M. G. van Pampus, J. de Vries
      BJOG 2015. DOI: 10.1111/1471-0528.13421
    • Clinician views and knowledge regarding healthcare provision in the postpartum period for women with recent gestational diabetes: a systematic review of qualitative/survey studiesE. Van Ryswyk, P. Middleton, W. Hague, C. CrowtherDiabetes Res Clin Pract 2014, 106(3) 401-11
    • Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial
      M. A. Rodger, W. M. Hague, J. Kingdom, S. R. Kahn, A. Karovitch, M. Sermer, et al.
      Lancet 2014, 384 (9955) 1673-83
    • Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications
      M. A. Rodger, M. Carrier, G. Le Gal, I. Martinelli, A. Perna, E. Rey, et al.
      Blood 2014, 123(6) 822-8
    • Gestational diabetes and obstetric cholestasis: a 10 year retrospective cohort review of outcomes and predictors
      J. Marathe, W. Lim, G. A. Dekker, W. M. Hague
      Diabetologia 2014, 57, S451
    • The role of L-arginine in the prevention and treatment of pre-eclampsia: a systematic review of randomised trials
      T. Dorniak-Wall, R. M. Grivell, G. A. Dekker, W. Hague, J. M. Dodd
      J Hum Hypertens 2014, 28(4) 230-5
    • Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes (MiG) Study
      H. L. Barrett, M. D. Nitert, H. D. McIntyre, W. M. Hague, L. Callaway, J. Rowan
      Journal of Diabetes & Metabolism 2014, 5(7) 1-8
    • Interventions for treating cholestasis in pregnancy. Gurung V, Middleton P, Milan S J, Hague W M, Thornton J G. Cochrane Database of Systematic Reviews, 2013.  doi: 10.1002/14651858.CD000493.pub2.
    • Metformin for women who are obese during pregnancy for improving maternal and infant outcomes. Eames A J, Grivell R M, Deussen A R, Hague W M, Dodd J M. Cochrane Database of Systematic Reviews, 2013.  doi: 10.1002/14651858.CD010564.
    • The DIAMIND Study: Postpartum SMS reminders to women who have had gestational diabetes mellitus to test for type 2 diabetes: a randomised controlled trial - study protocol. Heatley E M, Middleton P, Hague W M, Crowther C A. BMC pregnancy and childbirth 2013 13: 92
    • Vitamin B12 and homocysteine status during pregnancy in the Metformin in Gestational diabetes (MiG) trial: responses to maternal metformin compared with insulin treatment. Gatford K L, Houda C M, Lu Z, Coat S, Baghurst P, Owens J, Sikaris K, Rowan J A, Hague W M. Diabetes, obesity & metabolism 2013 doi: 10.1111/dom.12080
    • Determinants of maternal triglycerides in women with gestational diabetes mellitus in the Metformin in Gestational diabetes (MiG) study. Barrett H L, Nitert M D, Jones L, O'Rourke P, Lust K, Gatford K L, De Blasio M J, Coat S, Owens J A, Hague W M, McIntyre H D, Callaway L, Rowan J. Diabetes Care 2013 doi 10.2337/dc12-2132
    • Maternal and Neonatal Circulating Markers of Metabolic and Cardiovascular Risk in the Metformin in Gestational Diabetes (MiG) Trial: Responses to maternal metformin versus insulin treatment. Barrett H L, Gatford K L, Houda C M, De Blasio M J, McIntyre H D, Callaway L, Nitert M D, Coat S, Owens J A, Hague W M, Rowan J. Diabetes Care 36 (3), (2013): 529-536
    • A case of postpartum Group B streptococcal meningitis. Gayford K, McCarthy A, Hague W M. Obstetric Medicine 5(1), (2012): 25-26.
    • Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT. de Vries J I, van Pampus M G, Hague W M, Bezemer P D, Joosten J H, FRUIT Investigators. Journal of Thrombosis and Haemostasis 10(1), (2012): 64-72.
    • Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: the FRUIT-RCT: a reply to a rebuttal. de Vries J I, Hague W M, van Pampus M G, For the FRUIT investigators. Journal of Thrombosis and Haemostasis 10(6), (2012): 1196.
    • The IDEAL study: investigation of dietary advice and lifestyle for women with borderline gestational diabetes: a randomised controlled trial - study protocol. Crowther C A, Hague W M, Middleton P F, Baghurst P A, McPhee A J, Tran T S, Yelland L N, Ashwood P, Han S, Dodd J M, Robinson J S, IDEAL Study Group. BMC pregnancy and childbirth 12 (2012): 106
    • Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition at 2 years of age. Rowan J A, Rush E C, Obolonkin V, Battin M, Wouldes T, Hague W M. Diabetes Care 34(10), (2011): 2279-84.
    • A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart. Miragoli M, Kadir S H, Sheppard M N, Salvarani N, Virta M, Wells S, Lab M J, Nikolaev V O, Moshkov A, Hague W M, Rohr S, Williamson C, Gorelik J. Hepatology 54(4), (2011): 1282-92.
    • Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome. Furness D, Fenech M, Dekker G, Khong T Y, Roberts C, Hague W. Maternal and Child Nutrition. 2011. Epub 2011/10/26. doi 10.1111/j.1740-8709.2011.00364.x
    • Fractionated heparin in pregnant women with a history of Utero-placental Insufficiency and Thrombophilia, a randomised trial (the FRUIT study). de Vries J I, van Pampus M G, Hague W M, Bezemer P D, Joosten J H, FRUIT trial collaborators. Reproductive Sciences 18(3 suppl), (2011): 352A
    • Anti-diabetic agents for women with pre-existing diabetes mellitus/impaired glucose tolerance or previous gestational diabetes mellitus. Tieu J, Coat S, Hague W, Middleton P. Cochrane Database of Systematic Reviews 2010, Issue 10. Art. No.: CD007724. DOI: 10.1002/14651858.CD007724.pub2
    • Increased lymphocyte micronucleus frequency in early pregnancy is associated prospectively with pre-eclampsia and/or intrauterine growth restriction. Furness D L, Dekker G A, Hague W M, Khong T Y, Fenech M F. Mutagenesis 25(5), (2010): 489-98.
    • Glycemia and its relationship to outcomes in the MiG trial. Rowan J A, Gao W, Hague W M, McIntyre H D. Diabetes Care 33, (2010): 9-16
    • Long-term follow-up of women with gestational diabetes mellitus: the South Australian Gestational Diabetes Mellitus Recall Register. Chittleborough C, Baldock K, Taylor A, Hague W, Willson T, Martin W, Wood J, Phillips P. Aust N Z J Obstet Gynaecol, (2010): 10.1111/j.1479-828X.2010.01140.x

     

  • Professional Associations

    • Past President of the Australasian Society for the Study of Hypertension in Pregnancy
    • Founder Member and Convenor of the Obstetric Medicine Group of Australasia
    • First Honorary Member of the Society of Obstetric Medicine of Australia and New Zealand
    • Previous Council Member and Meetings Organiser of the International Society of Obstetric Medicine
    • Member of the International Society for the Study of Hypertension in Pregnancy 
    • Member of the Australasian Diabetes in Pregnancy Society
    • Fellow of the Royal Society of Medicine: Member of the Endocrinology and Obstetrics/Gynaecology sections.
    • Member of the Endocrine Society of Australia
    • Member of the Australian Menopause Society
    • Member of the Adelaide Clinical Endocrine Society
    • Member of the Adelaide Liver Research Group
    • Fellow of the Institute for the Study of Christianity in an Age of Science and Technology

     

The information in this directory is provided to support the academic, administrative and business activities of the University of Adelaide. To facilitate these activities, entries in the University Phone Directory are not limited to University employees. The use of information provided here for any other purpose, including the sending of unsolicited commercial material via email or any other electronic format, is strictly prohibited. The University reserves the right to recover all costs incurred in the event of breach of this policy.

Entry last updated: Monday, 27 Feb 2023

To link to this page, please use the following URL:  /directory/bill.hague