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• Biography/ Background

  • BMedSc (Hons) PhD

  Dr Vandyke is currently a Royal Adelaide Hospital Mary Overton Research Fellow in the Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, based at the South Australian Health and Medical Research Insititute (SAHMRI), Cancer Theme.

  Dr Vandyke's PhD research, completed in 2010, centred on characterising the off-target effects of tyrosine kinase inhibitors, like imatinib, on bone metabolism and skeletal growth in chronic myeloid leukaemia. Her current research interests involve elucidating the molecular and cellular mechanisms responsible for multiple myeloma disease progression, primarily focussing on investigating the mechanisms controlling myeloma dissemination.

  Dr Vandyke is an affiliate lecturer in the School of Medical Sciences and the School of Medicine, University of Adelaide. She is an elected member of the Haematology Society of Australia and New Zealand and has served on the committee of the Australian Society of Medical Research SA Division since 2014.

   

• Publications

  1.      Cheong, C.M., Chow A.W.S., Fitter S., Hewett D.R., Martin S.K., Williams S.A., To L.B., Zannettino A.C.W., Vandyke K. Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo. Experimental Cell Research (2015), 332(1):24-38.

  2.      Gan Z.Y., Fitter S., Vandyke K., To L.B., Zannettino A.C.W., Martin S.K. The effect of the dual PI3K and mTOR inhibitor BEZ235 on tumour growth and osteolytic bone disease in multiple myeloma. European Journal of Haematology (2015), 39(3):380-387-38.

  3.      Noll J.E., Hewett D.R., Williams S.A., Vandyke K., Kok C., To L.B., Zannettino A.C.W. SAMSN1 is a tumor suppressor gene in multiple myeloma. Neoplasia (2014), 16(7):572-585.

  4.      Noll J.E., Vandyke K., Zannettino A.C.W. The role of the “cancer stem cell niche” in cancer initiation and progression. Adult Stem Cell Niches. InTech (2014), Chapter 9, 291-320. ISBN: 978-953-51-1718-6.

  5.      Ahmed F., Dutta N.K., Zannettino A.C.W., Vandyke K., Choudhury N.R. Engineering interaction between bone marrow derived endothelial cells and electrospun surfaces for artificial vascular graft applications. Biomacromolecules (2014), 15(4):1276-1287.

  6.      Vandyke K., Chow A.W., Williams S.A., To L.B., Zannettino A.C.W. Circulating N-cadherin levels are a negative prognostic indicator in patients with multiple myeloma. British Journal of Haematology (2013), 161(4):499-507.

  7.      Vandyke K., Zannettino A.C.W. Side-effects of tyrosine kinase inhibitors on growth in paediatric patients. In ‘Imatinib: Chemical Structure, Pharmacology and Adverse Effects’. Nova Science Publishers (2013), Chapter 7, 115-128. ISBN: 978-1-62808-304-0.

  8.      Arthur A., Panagopoulos R., Cooper L., Menicanin D., Parkinson I., Codrington J., Vandyke K., Zannettino A.C.W, Koblar S.A., Sims N.A., Matsuo K., Gronthos S. EphB4 enhances the process of endochondral ossification during bone fracture repair. Journal of Bone and Mineral Research (2012), 28(4):929-35.

  9.      Vandyke K., Fitter S., Drew J., Fukumoto S., Schultz C.G., Sims N.A, Yeung D.T., Hughes T.P., Zannettino A.C.W. Prospective histomorphometric and DXA evaluation of bone remodelling in imatinib-treated CML patients: evidence for site-specific skeletal effects. Journal of Clinical Endocrinology and Metabolism (2013), 98(1):67-76.

  10.  Fitter S., Vandyke K., Gronthos S., Zannettino A.C.W. Suppression of PDGF induced PI3K activity by imatinib promotes adipogenesis and adiponectin secretion. Journal of Molecular Endocrinology (2012), 48(3):229-40.

  11.  Vandyke K., Fitter S., Zannettino A.C.W. The tyrosine kinase inhibitor dasatinib (SPRYCEL) inhibits chondrocyte activity and proliferation. Blood Cancer Journal (2011), 1(e2)doi:10.1038/bcj.2011.1.

  12.  Fitter S., Vandyke K., Schultz C.G., White D., Hughes T.P., Zannettino A.C.W. Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients? Journal of Clinical Endocrinology and Metabolism (2010), 95(8):3763-7.

  13.  Vandyke K., Dewar A.L., Diamond P., Fitter S., Schultz C.G., Sims N.A., Zannettino A.C.W. The tyrosine kinase inhibitor dasatinib dysregulates bone remodelling through inhibition of osteoclasts in vivo. Journal of Bone and Mineral Research (2010), 25(8):1759-70.

  14.  Vandyke K., Dewar A.L., Fitter S., Hughes T.P., Zannettino A.C.W. Dysregulation of bone remodelling by imatinib mesylate. Blood (2010), 115(4):766-774.

  15.  Vandyke K., Dewar A.L., Farrugia A.N., Fitter S., Menicanin D., To L.B., Hughes T.P., Zannettino A.C.W. Imatinib mesylate causes growth plate closure in vivo. Leukemia (2009), 23(11):2155-2159.

  16.  Vandyke K., Dewar A.L., Farrugia A.N., Fitter S., To L.B., Hughes T.P., Zannettino A.C.W. Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. Leukemia (2009), 23(5):994-997.

  17.  Vandyke K., White M.Y., Nguyen-Khuong T., Ow K., Luk S.C.-W., Kingsley E.A., Rowe A., Pang S.F., Walsh B.J., Russell P.J. Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo.      Neoplasia (2007), 9(4):322-331.

  18.  Vandyke K., Blair J.M., Jackson P. & Russell P.J. Androgen decreases osteoprotegerin expression in prostate cancer cells. Prostate Cancer Prostatic Dis (2007), 10(2):160-6.

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Entry last updated: Thursday, 5 Sep 2024

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