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• Biography/ Background

  Dr Martin Donnelley is a Senior Research Fellow at the University of Adelaide. He is the Leader of the Respiratory X-ray Imaging Laboratory (ReXIL), Co-Director of the Cystic Fibrosis Airway Research Group (CFARG) at the Women’s and Children’s Hospital, and a Robinson Research Institute Research Leader.

  Martin completed his PhD in Medical Image Processing at Flinders University in 2008, and has spent the last ten+ years developing world-leading gene therapy methodologies for cystic fibrosis (CF), as well as technologies for the measurement of in-vivo dynamic function in animal models.

  As the ReXIL Leader he has directed a program of X-ray imaging work that has enabled the imaging of airway surfaces at scales that have not previously been possible in-vivo. He and his collaborators published the first demonstration of the use of X-ray Velocimetry (XV), an X-ray based pulmonary function testing method, for the quantification of lung disease heterogeneity in B-ENaC mice. This unique imaging method gathers lung motion information during normal breathing to identify ventilation defects. His ReXIL team are partners with 4DMedical developing scanner hardware via a $29M MRFF grant.

  Martin’s CFARG team have developed a lentiviral gene vector system that corrects the CFTR defect in CF mouse nasal airways for at least 12 months. He has also championed the development of Adelaide-based CF rat models using CRISPR/Cas9 gene editing.

  All of this work has built towards a world leading capacity to perform rapid, non-invasive, direct, quantitative measurement of the effects of CFTR gene therapy on airway health and lung function.

   

• Qualifications

  2007 - PhD, Flinders University

  2001 - BEng (Biomedical) with Honours, Flinders University

  2000 - BSc, Flinders University

• Research Funding

  NHMRC

  Channel 7 Children's Research Foundation

  Australian CF Research Trust

  WCH Foundation

  Australian Synchrotron

  Robinson Research Institute (Travel grants: 2012-16)

• Publications

  A. McCarron, M. Donnelley, C. McIntyre, D. Parsons, “Challenges of up-scaling lentivirus production and processing”, Journal of Biotechnology, Accepted for publication, 2016.

  K. Morgan, T. Petersen, M. Donnelley, N. Farrow, D. Parsons, D. Paganin, “Capturing and visualizing transient x-ray topological features by single-grid phase imaging”, Optics Express, vol. 24(21) pp. 24435-24450, 2016.

  M. Donnelley, K. Morgan, N. Farrow, R. Carnibella, R. Murrie, A. Fouras, D. Parsons, “Alteration of Mouse Nasal Airway Surface Mucociliary Transit by Airway Rehydrating Agents”, SPring-8 Research Reports, Accepted for publication, 2016.

  C. Stahr, C. Samarage, D. Parsons, M. Donnelley, N. Farrow, K. Morgan, G. Zosky, R. Boucher, K. Siu, S. Dubsky, A, Fouras, “Quantification of heterogeneity in lung disease with image-based pulmonary function testing”, Scientific Reports, vol. 6, 2016.

  M. Donnelley, K. Morgan, K. Siu, N. Farrow, D. Parsons, “Non-Invasive Airway Health Measurement Using Synchrotron X-Ray Microscopy of High Refractive Index Glass Microbeads”, AIP Conf. Proc. vol. 1696, 020011, 2016.

  R. Murrie, K. Morgan, A. Maksimenko, A. Fouras, D. Paganin, C. Hall, K. Siu, D. Parsons, M. Donnelley, “Live small animal x-ray lung velocimetry and lung micro-tomography at the Australian Synchrotron Imaging and Medical Beamline”, Journal of Synchrotron Radiation, vol. 22, 2015.

  P. Cmielewski, M. Donnelley, N. Farrow, C. McIntyre, J. Penny-Dimri, T. Kuchel, D. Parsons, “Transduction of Ferret Airway Epithelia by a Lentiviral Gene Vector”, BMC Pulmonary Medicine, vol. 14(183), 2014.

  P. Cmielewski, M. Donnelley, D. Parsons, “Long term therapeutic and reporter gene expression in lentiviral vector treated cystic fibrosis mice”, Journal of Gene Medicine, vol. 16(9-10), 291-299, 2014.

  K. Morgan, M. Donnelley, N.Farrow, A. Fouras, R. Boucher, N. Yagi, Y. Suzuki, A. Takeuchi, K. Uesugi, K. Siu, D. Parsons, “In vivo x-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis”, American Journal of Respiratory and Critical Care Medicine, vol. 190, pp 469-472, 2014.

  M. Donnelley, K. Morgan, K. Siu, A. Fouras, N. Farrow, R. Carnibella, D. Parsons, “Tracking extended mucociliary transport activity of individual deposited particles: Longitudinal synchrotron imaging in live mice”, Journal of Synchrotron Radiation, vol. 21, 2014.

  M. Donnelley, K. Morgan, K. Siu, N. Farrow, C. Stahr, R. Boucher, A. Fouras, D. Parsons, "Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo", Scientific Reports, vol. 4(3689), 2014.

  N. Farrow, D. Miller, P. Cmielewski, M. Donnelley, R. Bright, D. Parsons, “Airway gene transfer in a non-human primate: Lentiviral gene expression in marmoset lungs”, Scientific Reports, 2013.

  M. Donnelley, K. Morgan, K. Siu, D. Parsons, “Variability of in vivo fluid dose distribution in mouse airways is visualized by high-speed synchrotron x-ray imaging”, Journal of Aerosol Medicine and Pulmonary Drug Delivery, vol. 26(0), 1-10, 2013.

  K. Morgan, M. Donnelley, D. Paganin, A. Fouras, N. Yagi, Y. Suzuki, A. Takeuchi, K. Uesugi, R. Boucher, D. Parsons, K. Siu, “Measuring airway surface liquid depth in live airways by x-ray imaging for the assessment of cystic fibrosis airway therapies”, PLOS ONE, vol. 8(1), 2013.

  K. Morgan, D. Paganin, D. Parsons, M. Donnelley, N. Yagi, K. Uesugi, Y. Suzuki, A. Takeuchi, K. Siu, “Single grating x-ray imaging for dynamic biological systems”, AIP Proceedings, vol. 1466, pp. 124-129, 2012.

  M. Donnelley, K. Morgan, K. Siu, D. Parsons, “Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour”, Journal of Synchrotron Radiation, vol. 19, pp. 551-558, 2012.

  M. Donnelley, K. Siu, A. Jamison, D. Parsons, “Synchrotron phase contrast X-ray imaging reveals fluid dosing dynamics in mouse airways”, Gene Therapy, vol. 19, pp. 8-14, 2012.

  M. Donnelley, D. Parsons, K. Morgan, K. Siu, “Animals In Synchrotrons: Overcoming Challenges For High-Resolution, Live, Small-Animal Imaging”, AIP Proceedings, vol. 1266, pp. 30-34, 2010.

  M. Donnelley, K. Siu, K. Morgan, W. Skinner, Y. Suzuki, A. Takeuchi, K. Uesugi, N. Yagi, D. Parsons, “A new technique to examine individual particle and fibre deposition and transit behaviour in live mouse trachea”, Journal of Synchrotron Radiation, vol. 17, pp. 719-729, 2010.

  K. Morgan, D. Paganin, D. Parsons, M. Donnelley, N. Yagi, K. Uesugi, Y. Suzuki, A. Takeuchi, and K. Siu, “Optimising Coherence Properties for Phase Contrast X-Ray Imaging (PCXI) to Reveal Airway Surface Liquid (ASL) as an Airway Health Measure”, IFMBE Proceedings, vol. 25/II, pp. 135-138, 2009

  M. Donnelley, K. Morgan, A. Fouras, W. Skinner, N. Yagi, K. Uesugi, K. Siu, D. Parsons, “Real-time non-invasive detection of inhalable particulates delivered into live mouse airways”, Journal of Synchrotron Radiation, vol. 16, pp. 553-561, 2009.

  D. Parons, K. Morgan, M. Donnelley, A. Fouras, J. Crosbie, I. Williams, R. Boucher, K. Uesugi, N. Yagi and K. Siu, “High Resolution Visualisation of Airspace Structures in Intact Mice via Synchrotron Phase Contrast X-ray Imaging (PCXI)”, Journal of Anatomy, vol. 213, pp 217-227, 2008.

  M. Donnelley, G. Knowles and T. Hearn “A CAD System for Long-bone Segmentation and Fracture Detection”, Image and Signal Processing. 3rd International Conference, ICISP, vol. 5099, pp 153-162, 2008

  M. Donnelley and G. Knowles, “Computer aided long bone fracture detection”, Proceedings of the Eighth International Symposium on Signal Processing and its Applications, vol. 1, pp 175-178, 2005.

  M. Donnelley and G. Knowles, “Automated Bone Fracture Detection”, SPIE Medical Imaging 2005: Image Processing, vol. 5747, pp 955-966, 2005.

  C. P. Rooney, M. Suter, G. McLennan, M. Donnelley, J. Reinhardt, A. Delsing, E. A. Hoffman, and J. Zabner, “Laser fluorescence bronchoscopy for detection of fluorescent reporter genes in airway epithelia”, Gene Therapy, vol. 9, pp. 1639-1644, 2002.

  D. Gopalakrishnan, G. McLennan, M. Donnelley, A. Delsing, M. Suter, D. Flaherty, J. Zabner, E. A. Hoffman, and J. M. Reinhardt, “Color analysis of the human airway wall”, SPIE Medical Imaging 2002: Physiology and Function from Multidimensional Images, vol. 4683, pp. 341-351, 2002.

Entry last updated: Tuesday, 2 May 2023

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