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• Biography/ Background

  Associate Professor Tony Hooker, B.Biotech (Hons), PhD, MARPS, MACPSEM

  Tony graduated with a PhD in Molecular Biology in 2002 from Flinders University. Tony has been a member of the Radiation Protection Branch of the South Australian (SA) Environment Protection Authority since 2007. He is currently Team Leader of the Radiation Health Group which is responsible for the licensing of all users and registration of ionising and non-ionising radiation apparatus used for scientific, industrial and medical purposes. In addition, he contributes to the administration and review of measures to maintain effective radiation protection legislation in SA and has been invited to participate in national workshops on radiation regulation by the Australian Radiation Protection and Nuclear Safety Agency. He provides expert advice to government, industry and the public regarding the health effects of radiation.

  Tony is currently Immediate Past President of the Australasian Radiation Protection Society (ARPS) and a member of the Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM). He is currently an Executive Member on the Asian and Oceanic Association for Radiation Protection (AOARP), and a member of the AOARP International Academic Advisors. He has been on organising committees for many national and international conferences. He is actively involved  in the organisation of workshops, seminars, related to radiationeducation and training. Tony is a member (radiation advisor) of the SA Chemical, Biological, Radiological and Nuclear Emergency Management Committee, and the SA CBRN Scientific Advisory and training Committees.

  Prior to working with the EPA, Tony was a Research Fellow at Flinders University and undertook research funded by the US Department of Energy Low Dose Radiation Research Program into the biological effects of low dose radiation exposure as well as the biological effects of radio-protector chemicals.

  Tony has published his research in peer-reviewed scientific journals, invited to write guest editorials and has been an invited speaker at a number of International and National meetings. He holds academic status with Flinders University (School of Medicine) and the University of Adelaide (School of Chemical Engineering) and has strong interests in radiation research.

• Qualifications

  2002         Doctor of Philosophy, Flinders University, South Australia
  1995 Bachelor of Biotechnology (Honours), Flinders University, South Australia

  Majors in molecular biology, microbiology and genetics.

• Research Funding

   

  GRANTS RECEIVED (Total = $6,723,821)

  2016     Dixon DL, Boreham D, Hooker A.M. Investigation of the Immunological Mechanisms of Ultra-Low and Low Dose Radiation. $536,000. Collaborative research program between the Northern Ontario School of medicine (Ontario, Canada), Bruce Power (Ontario, Canada) and Flinders University, South Australia.

  2014     Grano, S.R., Pring, A.O., Hooker, A.M., Spooner, N.A., D.J., Ngothai, Y.M., Ashman, P.J., Ebendorff-Heidepriem, H., Brugger, J., Wilson, S.A., Hayes, P.C., Peng, Y., Vaughan, J.W., Jak, E., Ehrig, K.J., Simons, S.J. ARC Research Hub for the Australian Copper-Uranium. $5,053,234

  2007     Hooker, A.M. and Sykes, P.J. The use of whole body low dose X-radiation to reduce tumorigenicity in a murine prostate model. Flinders University Seeding Grant. $21,012.

  2007     Hooker, A.M. and Sykes, P.J. Protection from chromosomal inversions by chemical radioprotectors. Flinders Medical Centre Foundation. $11,000.

  2007     Hooker, A.M. Cancer Council of SA Travel Grant. $2,750.

  2006     Sykes, P.J. and Hooker, A.M. The measurement of genetic damage (DNA inversions) in response to radiation. Australian Institute for Nuclear Science and Engineering (AINSE). $41,000.

  2006     Hooker, A.M. Cancer Council of SA Travel Grant. $2,750.

  2005     Sykes, P.J. and Hooker, A.M. Effect of low dose-rate radiation on somatic intrachromosomal recombination. Australian Institute for Nuclear Science and Engineering (AINSE). $24,100.

  2005     Sykes, P.J. and Hooker, A.M. Mechanism for non-linear mutation dose response to low dose and ultra-low doses of LET radiation. US Department of Energy. US$ 1,050,000.

  2005     Hooker. A.M and Sykes, P.J. Treatment of pKZ1 mice with radioprotectors. Flinders Medical Centre Foundation. $10,000.

  2005     Bryan, D-L. and Hooker, A.M. Breathing in chronic Heart failure: Is there novel pulmonary compensation? Flinders Institute for Health and Medical Research CRG. $3,000.

  2003     Hooker, A.M. Australian Institute for Nuclear Science and Engineering (AINSE) Young Investigator Travel Award. $500 + return airfare to Brisbane.

  2003     Hooker, A.M.  Cancer Council of SA Travel Grant. $2,000.

  2001     Hooker, A.M.  Anti-Cancer Foundation of SA Travel Grant. $225.

  1999     Sykes, P.J. and Hooker, A.M. The role of somatic intrachromosomal recombination in mutation and cancer in a transgenic mouse model.  Flinders University Research Budget. $2,250.

   

   

   

• Publications

   

  REFEREED JOURNAL ARTICLES

  Sykes, P.J., Hooker, A.M., Harrington, C.S., Jacobs, A.K., Kingsbury, L. and Morley, A.A. (1998). Induction of somatic intrachromosomal recombination inversion events by cyclophosphamide in a transgenic mouse model.  Mutation Research.  397: 209-219.

  Sykes, P.J., Hooker, A.M., and Morley, A.A. (1999). Inversion due to somatic intrachromosomal recombination produced by carcinogens in a transgenic mouse model. Mutation Research.  427: 1-9.

  Sykes, P.J., McCallum, B.D., Bangay, M.J., Hooker, A.M., and Morley, A.A. (2001). Effect of 900 MHz radiofrequency exposure on intrachromosomal recombination in pKZ1 mice.  Radiation Research.  156: 495-502.

  Hooker, A.M., Morley, A.A. and Sykes, P.J. (2002). Different doses of etoposide increase or decrease somatic intrachromosomal recombination in spleen of the pKZ1 mouse mutagenesis model. Mutation Research. 500: 117-124.

  Hooker, A.M., Morley, A.A., Tilley, W.D. and Sykes, P.J. (2004). Cancer associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. Mutation Research. 550:1-10.

  Hooker, A.M., Bhat, M., Lane, J., Morley, A.A. and Sykes, P.J. (2004). The linear no-threshold model does not hold for low dose ionising radiation.. Radiation Research. 162: 447-52.

  Sykes, P.J. Morley, A.A. and Hooker, A.M. (2006). The pKZ1 recombination mutation assay – a sensitive assay for low dose studies. Dose-Response. 4: 91-105.

  Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Scott, B.R., Turner, D.R. and Sykes, P.J. (2006). Extremely low priming doses of X-radiation induce an adaptive response for chromosomal inversions in pKZ1 mouse prostate. Radiation Research. 166: 757-766.

  Zeng, G., Day, T.K., Hooker, A.M., Blyth, B.J., Bhat, M., Tilley, W.D. and Sykes, P.J. (2006). Non-linear dose response in prostate after low dose radiation exposure. Mutation Research. 602: 65-73.

  Sykes, P.J., Day, T.K., Swinburne, S.J., Lane, J.M., Bhat, M., Morley, A.A and Hooker, A.M. (2006). In vivo mutagenic effect of VERY low dose radiation. Dose-Response. 4: 309-316.

  Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Scott, B.R., Turner, D.R. and Sykes, P.J. (2007). Adaptive response for chromosomal inversions in pKZ1 mouse prostate induced by low doses of X-radiation delivered after a high dose. Radiation Research. 167: 682-692.

  Day, T.K, Hooker, A.M., Zeng, G. and Sykes, P.J. (2007). Low dose X-radiation adaptive response in spleen and prostate of Atm heterozygous mice. International Journal of Radiation Biology. 83: 523-534.

  Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., Turner, D.R. and Sykes, P.J. (2007). Extremely low doses of X-radiation can induce adaptive responses in mouse prostate. Dose Response. 5: 315 -322.

  Hooker, A.M., Grdina, D.J., Murley, J.S., Blyth, B.J., Ormsby, R.J., Bezak, E., Giam, K.A., and Sykes, P.J. (2009). Low doses of amifostine protect from chromosomal inversions in spleen in vivo when administered after an occupationally relevant X-radiation dose Int. J. Low Radiation. 6: 43-56.

  Hooker, A.M. (2011). Radiation and risk: is it time for a regulatory threshold. Australas. Phys. Eng. Sci. Med. 34:299-301

  Li K., Pring, A., Etschmann, B., Macmillan, E., Ngothai, Y., O’Neill, B., Hooker, A., Mosselmans, F., and Brugger, J. Uranium scavenging during mineral replacement reactions. American Mineralogist. 100: 1728-1735

  Li, K., Pring, A., Etschmann, B., Rae, N., Reith, F., Ryan, C., Kirkham, R., Howard, D., Rosa, D., Zammit, C., Ngothai, Y., Hooker, A.M. and Brugger, J. (2016). Ore petrography using megapixel X-ray imaging: Rapid insights into element distribution and mobilisation in complex Pt and U-Ge-Cu ores. Economic Geology, 111:487-501.

   

  PUBLISHED ABSTRACTS

  Sykes, P.J., Hooker, A.M., McCallum, B.D., and Morley, A.A. (2001). Agents which reduce somatic intrachromosomal recombination below spontaneous frequency in the pKZ1 mutagenesis model. Environ. Mol. Mutagen. 37(S32): 40.

  Hooker, A.M., Morley, A.A. and Sykes, P.J* (2001). The effect of c-myc expression and loss of Msh2 expression on somatic intrachromosomal recombination. Environ. Mol. Mutagen. 37(S32): 74.

  Hooker, A.M., Morley, A.A., Tilley, W.D., and Sykes, P.J. (2003). Genes associated with cancer can affect somatic intrachromosomal recombination early in carcinogenesis. Environ. Mol. Mutagen. 41(3): 180.

  Sykes, P.J., Bhat, M., Cormack, J., Morley, A.A., Hooker, A.M. (2003). Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro.  Environ. Mol. Mutagen. 41(3): 208.

  Day, T.K., Hooker, A.M., Bhat, M., Cormack, J., Morley, A.A. & Sykes, P.J. (2004). Methylation as a potential mechanism of adaptive response after exposure to X-radiation. Environ. Mol. Mutagen. 44(3): 194.

  Hooker, A.M., Cormack, J., Domel, R.U., Burch, W.M., Swinburne, S.J., Morley, A.A. and Sykes, P.J. (2004). Non-Linear dose response to low doses of X-radiation. Environ. Mol. Mutagen. 44(3): 230.

  Sykes, P.J., Day, T.K., Zeng, G., Bhat, M., and Hooker, A.M. (2005). Non-linear somatic intrachromosomal recombination in vivo. 9^th International Conference on Environmental Mutagens. Mutation Research. 577: 22.

  Day, T.K., Zeng, G., Hooker, A.M., Bhat, M., and Sykes, P.J. (2005). Adaptive response in pKZ1 mouse prostate after exposure to very low doses of X-radiation. 9^th International Conference on Environmental Mutagens. Mutation Research. 577: 516.

  Hooker, A.M, Day, T.K., Grdina, D.J., Bhat, M. and Sykes, P.J. (2006). Amifostine reduces chromosomal inversions in pKZ1 spleen post X-irradiation. Environ. Mol. Mutagen. 47(6): 429.

   

  PAPERS PRESENTED AT LOCAL, NATIONAL AND INTERNATIONAL MEETINGS

  ·       *Denotes presenter.

  Sykes, P.J., Hooker, A.M., Harrington, C.S., Jacobs, A.K., Kingsbury, L. and Morley, A.A*. Induction of somatic intrachromosomal recombination inversion events by cyclophosphamide in a transgenic mouse model. 7th International Conference on Environmental Mutagens.  Toulouse, France.  September 1997.

  Hooker, A.M.*, Farrall, E.J., Harrington, C.S., Jacobs, A.K., Morley, A.A., and Sykes, P.J. Induction of intrachromsomal recombination by DNA damaging agents in a transgenic mouse model.  36th National Scientific Conference. The Australian Society for Medical Research.  Adelaide, South Australia.  25th November, 1997.

  Hooker, A.M.*, Morley, A.A. and Sykes, P.J. Over-expression of c-myc induces intrachromosomal recombination in a transgenic mouse model. The International Human Genome Meeting.  Brisbane, Australia. 27th-30th March, 1999.

  Sykes, P.J.*, Hooker, A.M. and Morley, A.A. Inversion due to intrachromosomal recombination produced by carcinogens in a transgenic mouse model.  The International Human Genome Meeting.  Brisbane, Australia. 27th-30th March, 1999.

  Hooker, A.M.*, Morley, A.A. and Sykes, P.J. Different doses of etoposide cause a biphasic response in somatic intrachromosomal recombination in spleen of the pKZ1 mouse mutagenesis model. The Australian Society for Medical Research – Research Week.  Adelaide, Australia.  9th June, 2000.

  Sykes, P.J.*, McCallum, B.D., Bangay, M.J., Hooker, A.M., and Morley, A.A. Effect of 900 MHz radiofrequency exposure on intrachromosomal recombination in pKZ1 mice.  Clinical Oncological Society of Australia – Scientific Meeting.  Adelaide, Australia.  29th Nov – 1st Dec, 2000.

  Hooker, A.M.*, Morley, A.A. and Sykes, P.J. The effect of c-myc expression and loss of msh2 expression on somatic intrachromosomal recombination in the pKZ1 mutagenesis model.  13^th Lorne Cancer Conference.  Lorne, Australia.  8th – 11th February, 2001.

  Sykes, P.J.*, Hooker, A.M., Turner, D.R., McCallum, B.D., and Morley, A.A. Reduction of somatic intrachromosomal recombination below spontaneous frequency in the pKZ1 recombination mutagenesis model in response to DNA damaging agents and a mismatch repair deficiency.  Genetics Society of Australia.  48^th General Meeting.  Adelaide, Australia.  3rd – 7th July, 2001.

  Hooker, A.M.*, Horne, R., Morley, A.A. and Sykes, P.J. The effect of etoposide on somatic intrachromosomal recombination: a comparison in in vivo and in vitro pKZ1 murine models.  Genetics Society of Australia.  48^th General Meeting.  Adelaide, Australia.  3rd – 7th July, 2001.

  Day, T.K.*, Hooker, A.M., Bhat, M., Cormack, J., Morley, A.A., Sykes, P.J. Characterisation of an adaptive response in pKZ1 mice after exposure to X-radiation. 12^th International Congress of Radiation Research.  Brisbane, Australia.  17^th – 22^nd August, 2003

  Hooker, A.M.*, Bhat, M., Cormack, J., Morley, A.A. and Sykes, P.J. Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro. 12^th International Congress of Radiation Research.  Brisbane, Australia.  17^th – 22^nd August, 2003.

  Sykes, P.J.*, Day, T.K., Swinburne, S.J., Bhat, M., Cormack, J., Lane, J.M., Morley, A.A. and Hooker, A.M. Effect of low dose radiation on somatic intrachromosomal recombination in vivo and in vitro. DOE Low Dose Radiation Research Program. Investigator Workshop IV. Bethesda, Maryland, USA. 2003.

  Sykes, P.J.*, Day, T.K., Swinburne, S.J., Lane, J.M., Bhat, M., Morley, A.A. and Hooker, A.M. In vivo mutagenic effect of very low dose radiation.14^th Pacific Basin Nuclear Conference (PBNC). Honolulu, Hawaii, USA. 21^st – 25^th March, 2004.

  Sykes, P.J.*, Bhat, M., Day, T.K., Swinburne, S.J., Cormack, J., Domel, R.U., Burch, W., Morley, A.A. and Hooker, A.M. In vivo mutagenic effect of very low dose radiation.  Modelling of tumour development behaviour and response to treatment in clinical oncology meeting. Adelaide, Australia.  21^st – 23^rd May, 2004.

  Sykes, P.J.*, Swinburne, S.J., Bhat, M., Cormack, J., Day, T.K., Domel, R.U., Burch, W., Morley, A.A. and Hooker, A.M. Are low doses of DNA damaging agents anti-mutagenic?  3^rd annual Non-linear Dose-Response Relationships in Biology, Toxicology and Medicine.  Amherst, Massachusetts, USA.  8^th – 10^th June, 2004.

  Hooker, A.M.*, Cormack, J., Domel, R.U., Burch, W.M., Swinburne, S.J., Morley, A.A. and Sykes, P.J. Non-Linear dose response to low doses of X-radiation. 29^th Australian Radiation Protection Society Conference. Adelaide, Australia. 24^th – 27^th October,2004.

  Swinburne, S.J.*, Hooker, A.M., Bhat, M., Morley, A.A. and Sykes, P.J. Somatic intrachromosomal recombination in Atm heterozygous transgenic mice after low dose X-radiation exposure. 29^th Australian Radiation Protection Society Conference. Adelaide, Australia. 24^th – 27^th October, 2004.

  Day, T.K.*, Hooker, A.M., Bhat, M., Cormack, J., Morley, A.A. & Sykes, P.J. Methylation as a potential mechanism of adaptive response after exposure to X-radiation. 29^th Australian Radiation Protection Society Conference. Adelaide, Australia. 24^th – 27^th October, 2004.

  Sykes, P.J.* Zeng, G., Day, T.K., Morley, A.A. and Hooker, A.M. The pKZ1 inversion assay is a sensitive assay for low-dose X-radiation studies. DOE Low Dose Radiation Research Program. Investigator Workshop V. Bethesda, Maryland, USA. 25^th – 27^th April, 2005.

  Sykes, P.J.*, Day, T.K., Swinburne, S.J., Zeng, G. and Hooker, A.M. Complex mutagenesis dose-response relationships after exposure of pKZ1 mice to DNA damaging agents. 4^th International Conference on Hormesis: Implications for toxicology, medicine and risk assessment. The Annual Meeting of the International Hormesis Society. Amherst, Massachusetts, USA. 6^th – 8^th June, 2005.

  Day, T.K., Zeng, G. Hooker, A.M., Bhat, M. and Sykes, P.J.* Adaptive response in pKZ1 mouse prostate after exposure to very low doses of X-radiation. 4^th International Conference on Hormesis: Implications for toxicology, medicine and risk assessment. The Annual Meeting of the International Hormesis Society. Amherst, Massachusetts, USA. 6^th – 8^th June, 2005.

  Sykes, P.J., Zeng, G., Hooker, A.M., Bhat, M. and Day, T.K. The linear no-threshold model does not hold for low dose ionizing radiation. Engineering and Physical Sciences in Medicine Meeting. Adelaide, Australia. 24^th -26^th October, 2005.

  Day, T.K., Zeng, G., Hooker, A.M., Turner, D.R. and Sykes, P.J.*. Induction of adaptive responses in mouse prostate using very low doses of radiation. Radiation 2006. Australian Institute of Nuclear Science and Engineering Meeting, University of Sydney, NSW, Australia. 20^th – 21^st April, 2006.

  Hooker, A.M.*, Zeng, G., Domel, R., Burch, W., and Sykes, P.J. Comparison of low dose X- and g-radiation exposure on chromosomal inversions in the pKZ1 assay. Radiation 2006. Australian Institute of Nuclear Science and Engineering Meeting, University of Sydney, NSW, Australia. 20^th – 21^st April, 2006.

  Day, T.K., Hooker, A.M., Zeng, G., Grdina, D.J., Scott, B.R. and Sykes, P.J.* Adaptive and reverse adaptive responses for chromosomal inversions in pKZ1 mouse prostate: hints on mechanism. DOE Low Dose Radiation Research Program. Investigator Workshop VI. Washington DC, USA 2006.

  Day, T.K.*, Zeng, G., Hooker, A.M., Bhat, M., Turner, D.R. and Sykes, P.J. Adaptive response in pKZ1 mouse prostate after whole body exposure to very low X-radiation doses. 5^th International Conference, Hormesis: implications for toxicology, medicine and risk assessment, Amherst, Massachusetts, USA. June 6-8^th, 2006.

  Hooker, A.M.*, Zeng, G., Domel, R., Burch, W. and Sykes, P.J. Comparison of low dose X- and g-radiation exposure on chromosomal inversions in the pKZ1 assay. Australasian Radiation Protection Society Conference, Coogee Beach, NSW, Australia, 26^th-29^th November 2006.

  Hooker, A.M.*, Day, T.K., Grdina, D.J., Bhat, M. and Sykes, P.J. Amifostine reduces chromosomal inversions in pKZ1 spleen post X-irradiation. Australasian Radiation Protection Society Conference, Coogee Beach, NSW, Australia, 26^th-29^th November 2006.

  Hooker, A.M. *. Regulation of Solaria in South Australia: How hard was it? Australasian Radiation Protection Society Conference. Canberra, ACT, Australia, 21^st – 24^th September 2008.

  Eitzen, D. Wills, S.*, and Hooker A.M. Too hot to handle; Dealing with the potentially radioactive body. International Symposium of the Australian and New Zealand Forensic Science Society. Hobart, Tasmania, Australia, 23^rd - 27^th September 2012.

  Hooker, A.M.*, Key Challenges for Present and Future radiation Protection Agencies – an Australian Perspective, AOCRP-4 IRPA Regional Congress, Kuala Lumpur, Malaysia 12^th – 16^th May 2014.

   

• Professional Associations

  PROFESSIONAL ASSOCIATIONS/ MEMBERSHIPS

  2011 – present              Member, Australasian College of Physical Scientists in Engineering and Medicine

  2010 – present              Member, Association of Professional Engineers, Scientists and Managers, Australia

  2006 – 2008                  Member, Environmental Mutagen Society (USA)

  2006 – present              Member, Australasian Radiation Protection Society

  1998 – 2008                  Member, Australian Society for Medical Research

  1998 – 2008                  Member, Human Genetics Society of Australasia

   

  SERVICE TO COMMITTEES

  2015 – present             Immediate Past President, Australasian Radiation Protection Society

  2014 – present             International Congress Scientific Committee, IRPA 14, International Radiation Protection Association

  2013 – present             Executive Member, Asian and Oceanic Radiation Protection Association

  2013 – present             Member, International Academic Advisors, Asian and Oceanic Radiation Protection Association

  2013 – 2015                  President, Australasian Radiation Protection Society

  2011 – 2013                  Vice President, Australasian Radiation Protection Society

  2010 – present             Founding member, Secretary and Public Officer, Network of Environmental Professionals - SA

  2010 – 2013                  Chair, SA Branch Australasian Radiation Protection Society

  2009 – present             Radiation Advisor, State (SA) CBRN Scientific Advisory Committee

  2009 – present             Radiation Advisor, State (SA) CBRN Emergency Management Committee

  2009 – present             Radiation Advisor, State (SA) CBRN Training Committee

  2009 – 2013                  Radiation Advisor, SA Health Emergency Management Response Clinical Advisory Committee

  2007 – present             Member, SA Branch Australasian Radiation Protection Society Committee

  2006 – 2006                  Deputy Co-Convenor, Australian Society for Medical Research (SA Branch) committee

  2005 – 2006                  Member, Australian Society for Medical Research (SA Branch) committee

  2005 – 2007                  Member, School of Medicine Animal Ethics Review Sub-Committee

  2005 – 2007                  Member, Faculty of Health Sciences Staff Consultation Committee

  2000 – 2002                  Student Board Member, Flinders Medical Research Institute

Entry last updated: Saturday, 12 Aug 2023

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